If you haven’t been able to use the middle mouse button in any of the computers that you try, there is something wrong with the hardware. If you can, disconnect your mouse from your PC and connect it to another one. The first thing that you need to do is to troubleshoot the mouse on another computer. Method #1: Connect your Mouse to Another PC Today I will show you how I want to share with the several ways that you can try to fix your middle mouse button on Windows. As you will see, one of the most common failures that you can find in a mouse is when the middle button is not working, even when you own a gamer mouse that supposedly can receive heavy use.